What is beta-lactamase and why is it important?

Rudolf Phebus asked, updated on July 8th, 2022; Topic: beta-lactamase
👁 447 👍 14 ★★★★☆4.1

Beta-lactamases are an important group of bacterial enzymes, which preferentially cleave the beta-lactam ring of penicillins, cephalosporins, or other medically important beta-lactam antibiotics (Fig. 1).

Follow this link for full answer

Besides this, how does beta-lactamase destroy penicillin?

Penicillin's mechanism of action Penicillin and other antibiotics in the beta-lactam family contain a characteristic four-membered beta-lactam ring. Penicillin kills bacteria through binding of the beta-lactam ring to DD-transpeptidase, inhibiting its cross-linking activity and preventing new cell wall formation.

Same, how does beta-lactamase protect a resistant cell? Penicillins & cephalosporins share a common four-atom beta-lactam ring. Beta-lactamases are a family of enzymes produced by some gram-negative bacteria that provide a resistance to beta-lactam drugs by breaking the ring open by hydrolysis, which eliminates the molecule's antibacterial actions.

Then, how does Gram-positive bacteria respond to antibiotics?

Gram-positive bacteria, those species with peptidoglycan outer layers, are easier to kill - their thick peptidoglycan layer absorbs antibiotics and cleaning products easily. In contrast, their many-membraned cousins resist this intrusion with their multi-layered structure.

Why is Clavulanic acid is added to penicillin?

Introduction. Clavulanic acid is used with beta-lactamase sensitive penicillins to protect them against the hydrolysis of their beta-lactam ring and so rendering them effective against beta-lactamase producing bacteria.

12 Related Questions Answered

What are antibiotics explain?

Antibiotics are medicines that fight bacterial infections in people and animals. They work by killing the bacteria or by making it hard for the bacteria to grow and multiply. Antibiotics can be taken in different ways: Orally (by mouth). This could be pills, capsules, or liquids.

Why is beta-lactamase important in medicine?

Medical uses The most important use of beta-lactamase inhibitors is in the treatment of infections known or believed to be caused by gram-negative bacteria, as beta-lactamase production is an important contributor to beta-lactam resistance in these pathogens.

Is imipenem a carbapenem?

Imipenem/cilastatin is the first of a new class of beta-lactam antibiotics called carbapenems. The antibacterial spectrum of imipenem exceeds any antibiotic investigated to date and includes gram-positive, gram-negative, and anaerobic organisms.

Which is a beta lactamase inducer?

In cytoplasm, anhydro-MurNAc-oligopeptide are the inducer of beta-lactamase expression through the interaction with AmpR (Lindquist et al., 1989; Jacobs et al., 1997).

What does inducible beta-lactamase mean?

Inducible beta-lactamases belong into class I according to Richmond and Sykes. They are chromosomally mediated cephalosporinases. ... Induction of beta-lactamase caused by these substances can lead to antagonism with other beta-lactam antibiotics if they are used in combination.

What bacteria can produce beta-lactamase?

Extended-spectrum beta-lactamases (ESBL) are enzymes produced by gram-negative bacteria such as Klebsiella pneumoniae and Escherichia coli (24) as well as by species from other genera, such as Enterobacter sp., Salmonella sp., Proteus sp., Serratia marcescens, Shigella dysenteriae, Pseudomonas aeruginosa, and ...

What is a beta-lactamase resistant penicillin?

A penicillin antibiotic used to treat a number of susceptible bacterial infections. Meticillin. Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins.

Do beta-lactam antibiotics work on Gram-negative bacteria?

Beta-lactam antibiotics, which are named for the beta-lactam ring in their chemical structure,1 include the penicillins, cephalosporins and related compounds. These agents are active against many gram-positive, gram-negative and anaerobic organisms.

Why do antibiotics work better on Gram positive bacteria?

Antibiotics: mode of action It is specific to bacteria because only bacteria have this polymer in their cell wall, and it is more effective against Gram positive bacteria because they have a much thicker layer of peptidoglycan in their cell wall than Gram negative bacteria.

Why is it important to know Gram positive or negative?

The main benefit of a gram stain is that it helps your doctor learn if you have a bacterial infection, and it determines what type of bacteria are causing it. This can help your doctor determine an effective treatment plan.

Why do Gram positive and Gram negative bacteria respond differently to antibiotics?

Why do Gram positive and Gram negative bacteria show different antibiotic susceptibility patterns? The terms Gram positive and Gram negative are commonly used to describe bacteria. The main difference between the two is the structure of their cell wall which changes their susceptibility to different antibiotics.

What is the role of clavulanic acid?

It works by stopping the growth of bacteria. Clavulanic acid is in a class of medications called beta-lactamase inhibitors. It works by preventing bacteria from destroying amoxicillin. Antibiotics will not work for colds, flu, or other viral infections.