Normally, AST levels in your blood are low. When your liver is damaged, it puts more AST into your blood, and your levels rise. A high AST level is a sign of liver damage, but it can also mean you have damage to another organ that makes it, like your heart or kidneys.
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Again, what causes high ALT and AST levels?
Chronic alcohol consumption, drugs, non-alcoholic steatohepatitis (NASH) and chronic viral hepatitis are common causes associated with raised ALT and AST. In chronic viral hepatitis, the elevation of liver enzyme may not correlate well with the degree of liver damage.
In addition to it, what does a low AST level indicate? Low AST Levels The reference ranges are based on where 95% of the healthy population falls into, which means that there are 5% of the people who are healthy and not within the reference range! However, in rare cases, low AST may signal vitamin B6 deficiency, because the AST enzyme requires vitamin B6 to function.
In all cases, what is a normal AST value?
The normal range is 8 to 33 U/L. Normal value ranges may vary slightly among different laboratories.
What level of AST indicates liver damage?
An AST/ALT ratio higher than one (where the AST is higher than ALT) means you may have cirrhosis. An AST/ALT ratio higher than 2:1 (where the AST is more than twice as high as the ALT) is a sign of alcoholic liver disease.
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Natural ways to lower ALT levelsDrinking coffee. Drinking coffee can help to lower ALT levels. ... Exercising regularly. ... Losing excess weight. ... Increasing folic acid intake. ... Making dietary changes. ... Reducing high cholesterol. ... Taking care with medications or supplements. ... Avoiding alcohol, smoking, and environmental toxins.
Higher-than-normal amounts of this enzyme in your blood may be a sign of a health problem. Abnormal levels can be associated with liver injury. AST levels increase when there's damage to the tissues and cells where the enzyme is found. AST levels can rise as soon as six hours after damage to tissue occurs.
Typically the range for normal AST is reported between 10 to 40 units per liter and ALT between 7 to 56 units per liter. Mild elevations are generally considered to be 2-3 times higher than the normal range. In some conditions, these enzymes can be severely elevated, in the 1000s range.
Causes of low AST: uremia, vitamin B6 deficiency (this can be corrected), metronidazole, trifluoperazine. Causes of high AST: chronic alcohol ingestion, not limited to overt chronic alcoholism; cirrhosis. In alcoholic hepatitis, AST values usually are <300 units/L.
The normal range of values for AST (SGOT) is about 5 to 40 units per liter of serum (the liquid part of the blood). The normal range of values for ALT (SGPT) is about 7 to 56 units per liter of serum.
With acute Hepatitis, AST levels usually stay high for about 1-2 months but can take as long as 3-6 months to return to normal.
LABORATORY EVALUATION. Laboratory abnormalities often are the only sign of non-alcoholic fatty liver disease. The most common abnormal laboratory test results are elevated alanine transaminase (ALT) and aspartate transaminase (AST), usually one to four times the upper limits of normal.
Nonalcoholic Fatty Liver Disease. A systematic review found that NAFLD is the most common cause of asymptomatic elevation of transaminase levels (25% to 51% of patients with elevated ALT or AST, depending on the study population).
If liver damage is the cause of elevated liver enzymes, you may have symptoms such as:
- Abdominal (stomach) pain.
- Dark urine (pee).
- Fatigue (feeling tired).
- Jaundice (yellowing of your skin or eyes).
- Light-colored stools (poop).
- Loss of appetite.
- Nausea and vomiting.
High levels of ALT may indicate liver damage from hepatitis, infection, cirrhosis, liver cancer, or other liver diseases. Other factors, including medicines, can affect your results. Be sure to tell your health care provider about all the prescription and over-the counter medicines you are taking.
Serum aminotransferase levels—ALT and AST—are two of the most useful measures of liver cell injury, although the AST is less liver specific than is ALT level. Elevations of the AST level may also be seen in acute injury to cardiac or skeletal muscle.
A normal AST:ALT ratio should be <1. In patients with alcoholic liver disease, the AST:ALT ratio is >1 in 92% of patients, and >2 in 70%. AST:ALT scores >2 are, therefore, strongly suggestive of alcoholic liver disease and scores <1 more suggestive of NAFLD/NASH.
AST tends to run slightly higher in males than females due to differences in body mass and varies with age. AST is slightly higher than ALT until the age of 15 to 20 years. Thereafter, AST activity tends to be lower than ALT. At age 60, AST and ALT activities become roughly equal.