A drug regimen of clopidogrel plus aspirin is advised for one month for patients with bare metal stents and for six to 12 months in patients with a so-called drug-eluting stent, which is coated with medication to help prevent the artery from becoming blocked again.
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Along with that, can you ever stop taking Plavix?
CHICAGO (Reuters) - Patients given the blood-clot preventer Plavix after a heart attack or after receiving a stent have a far higher risk of heart attack or death in the three months after they stop taking the drug, U.S. researchers said on Tuesday.
For this reason, what happens if you stop taking blood thinners after a stent? The highest risk of clotting comes within the first month after stenting, where stopping even one of those drugs is associated with a very high risk of sudden clotting of the stent and a subsequent heart attack. With longer time elapsed since the placement, the risk of stent closure decreases.
Over and above that, should Plavix be taken long term?
Safety Announcement. [ 11-06-2015 ] A U.S. Food and Drug Administration (FDA) review has determined that long-term use of the blood-thinning drug Plavix (clopidogrel) does not increase or decrease overall risk of death in patients with, or at risk for, heart disease.
When can I stop taking Plavix?
Early clopidogrel (Plavix) withdrawal (i.e., less than six weeks after bare-metal stents, less than six months after acute coronary syndrome, less than 12 months after drug-eluting stents) should be avoided because it is the main predictor of coronary thrombosis.
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The standard recommendation is typically at least 12 months of Plavix. But the study found that six months of treatment was enough to prevent rare but deadly complications, says researcher Marco Valgimigli, MD, of the University Hospital of Ferrara, in Italy.
Do not stop taking clopidogrel without talking to your doctor. If you stop taking clopidogrel, your blood will start clotting at the same rate as before you started taking it, usually within 5 days of stopping the medicine. This means you may be at increased risk of serious problems like heart attacks or strokes.
Contrary to some recent reports indicating a full 12 months of dual antiplatelet therapy following percutaneous coronary intervention (PCI) is unnecessary, a large Danish registry study shows that halting clopidogrel after 1 year raises the risk of death and reinfarction in myocardial infarction (MI) patients.
Symptoms will usually tell you if there's a problem. If that happens, you usually have symptoms—like chest pain, fatigue, or shortness of breath. If you do have symptoms, a stress test can help your doctor see what's going on. It can show if a blockage has returned or if there's a new blockage.
Take as directed Clopidogrel oral tablet is used for long-term treatment. It comes with serious risks if you don't take it as prescribed. If you stop taking the drug or don't take it at all: You increase your risk of heart attack or stroke. These conditions can be fatal.
Aspirin combined with the antiplatelet drug clopidogrel is no better than aspirin alone for stroke prevention in people with a history of lacunar strokes, and the combination carries a greater risk of gastrointestinal bleeding, according to results of a trial funded by the National Institutes of Health.
The severity of liver injury associated with clopidogrel ranges from transient, mild serum enzyme elevations to clinically apparent acute hepatitis that can be severe and lead to death. Most cases resolve with drug withdrawal within 1 to 3 months.
Conclusions: Long term dual anti-platelet therapy with aspirin 81 mg daily and clopidogrel 75 mg every other day beyond 12 months after PCI with DES may be a safe and efficacious cost-saving strategy to prevent VLST.
Easy bleeding/bruising, stomach upset/pain, diarrhea, and constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.
Plavix is estimated to be cleared from your body in about 33 hours. A single, oral dose of Plavix (clopidogrel) 75 mg has a half-life of approximately 6 hours. It takes 5.5 x half-life of a medicine for a drug to leave the body, therefore most of the Plavix should be eliminated from your system in 5.5 x 6 = 33 hours.
Nov. 17, 2009 - The FDA today warned patients not to combine Plavix with Nexium, Prilosec, and nine other drugs -- including Prozac and Tagamet. The drugs may make the anti-clotting drug Plavix dangerously less effective, the FDA says. They block an enzyme in the body that turns the drug into its active form.
Treatment with clopidogrel is usually for life, unless there are any reported problems. In the UK, medicines must have a licence, also called a Marketing Authorisation (MA), before they are approved for treating patients.
The optimal duration of dual antiplatelet therapy is not known; 12 months has been the commonly recommended duration. A recent large trial changed recommendations. Rates of stent thrombosis and death from stroke or heart attack were lower when the two meds were continued for 18 more months.
Brilinta has been marketed and studied as a more effective drug than Plavix. It has been shown to be a better drug for reducing rates of cardiovascular death and preventing heart attack or stroke.
Tell your doctor if you have serious side effects of Plavix including:
- bleeding that will not stop;
- bloody or tarry stools, blood in your urine;
- coughing up blood or vomit that looks like coffee grounds;
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
How long will a stent last? It is permanent. There is just a 2–3 per cent risk of narrowing coming back, and if that happens it is usually within 6–9 months. If it does, it can potentially be treated with another stent.
After drug-eluting stent placement, you need to take aspirin and a stronger prescription blood thinner such as clopidogrel (Plavix) to prevent blood clotting in the stent. You may need to take a daily aspirin for the rest of your life.
Clopidogrel may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- excessive tiredness.
- stomach pain.
Conclusions. In summary, among patients hospitalized with ACS and treated with clopidogrel, lower levels of kidney function were associated with a greater risk of death, hospitalization for AMI, and major bleeding.
You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it in the morning, as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.
Safer Blood-Thinning Drugs to Prevent Stroke The newer medications are Pradaxa (dabigatran), Xarelto (rivaroxaban), Eliquis (apixaban), and most recently Savaysa (edoxaban) — which work by preventing pooled blood in the heart from clotting. Unlike warfarin, the newer drugs are safer and easier for patients to use.
These medications are used to slow blood clotting and include aspirin, clopidogrel (Plavix), ibuprofen (Advil, Motrin, and others), naproxen (Anaprox, Naprosyn, and others), enoxaparin (Lovenox), and more. Health experts advise caution when combining them with coffee, which can also slow blood clotting.
Eating grapefruit or drinking the juice can also lead to bleeding. Grapefruit mostly impacts blood-thinning medications such as Apixaban (Eliquis), Rivaroxaban (Xarelto), Clopidogrel (Plavix) and Ticagrelor (Brilinta). If you're taking one of these medications and crave that citrus flavor, Dr.